It is important for researchers to carefully assess the feasibility of a clinical trial prior to the launch of the study.One feasibility aspect that JACKETS PUFFA needs to be considered includes whether investigators can expect to successfully achieve the sample size needed for their trial.In this manuscript, we present a Bayesian design in which d
A stringent control of homeostasis is critical for functional maintenance and survival of neurons.In the mammalian retina, the basic motif leucine zipper transcription factor NRL determines rod versus cone photoreceptor cell fate and activates the expression of many rod-specific genes.Here, we report an integrated analysis of NRL-centered gene regu
Abstract Background Glioma is the most commonly diagnosed malignant and aggressive brain cancer in adults.Traditional researches mainly explored the expression profile of glioma at cell-population level, but ignored the heterogeneity and interactions of among glioma cells.Methods Here, we firstly analyzed the single-cell RNA-seq (scRNA-seq) data of
INTRODUCTION: Neonatal mortality remains a significant public health burden worldwide, with about 4 million deaths per year.To provide evidence for the implementation of prevention measures aimed at the reduction of neonatal mortality, we performed a study on factors associated with neonatal mortality at the Referral Hospital in Nouakchott, Maurita